Edin Dzeko terminated a late possibility over.
Schalke originated from 2-0 down, and 3-1 on total, to beat Bundesliga rivals Borussia Monchengladbach on away objectives.
Andreas Christensen and Mahmoud Dahoud had placed Gladbach in charge before Leon Goretzka’s strike and Nabil Bentaleb’s punishment.
Ryan Babel scored his initial two European objectives since 2010 as 10-man Besiktas beat Olympiakos 4-1 in Istanbul, 5-2 on total.
Celta Vigo, Spain’s just agents left in the competition, beat FK Krasnodar 2-0 in Russia to advance 4-1 in general.
Bertrand Traore and Kasper Dolberg scored as Ajax beat FC Copenhagen 2-0 to topple a 2-1 first-leg shortfall to advance.
Anderlecht beat Apoel Nicosia 1-0 (2-0 on total), while Genk beat kindred Belgians Gent 6-3 on total following a 1-1 second-leg draw.
Manchester United beat FC Rostov 1-0 to experience 2-1 in general.